Targeting Protein Misfolding(Islet Amyloid Polypeptide) using Helical Mimetics
نویسندگان
چکیده
منابع مشابه
A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.
A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.2112